Panadol extra effervescent tablets instructions for use. Panadol Extra - description of the drug, instructions for use, reviews. Indications for use of Panadol Extra

Instructions

Panadol Extra, as its name suggests, is intended to relieve pain. The drug is becoming increasingly popular among patients.

Name

Tradename

Same as the traditional name.

International nonproprietary name

Absent.

Latin name

Pharmacological group

Analgesic of non-narcotic origin.

Release forms and composition

The product is produced in the form of tablets, each of which contains 500 mg of paracetamol and 65 mg of caffeine. If the tablets are effervescent, the content of active ingredients in them is the same.

Mechanism of action of Panadol Extra

Pharmacodynamics

The effects that can be achieved when using the drug for medicinal purposes are antipyretic and analgesic. Paracetamol is needed to reduce elevated body temperature and eliminate pain. Caffeine as an integral component of the medicine is intended to relieve feelings of fatigue and drowsiness. At the same time, it increases the heart rate and increases blood pressure.

Pharmacokinetics

Metabolism of the drug occurs in the liver. Absorption from the digestive tract can be characterized as good. Distribution occurs throughout all tissues of the body. All metabolites and main components of the drug are excreted from the patient’s body through the kidneys.

Indications for use of Panadol Extra

The drug can be used to eliminate pain in the event of the development of:

• headache;
• toothache;
• painful menstruation;
• spasms in the lower back;
• migraine;
• sore throat;
• upper respiratory tract infections.

The drug also helps lower body temperature and eliminate symptoms of flu or colds. When treating respiratory tract pathologies, combined use of the drug with other drugs is possible.

Contraindications

You should not take the drug if the patient has a history of:

• increased sensitivity to the main component of the drug;
• severe atherosclerosis;
• Gilbert's syndrome;
• blood diseases;
• sleep disorders;
• glaucoma.

Dosage regimen for Panadol Extra

It is advisable to discuss the dosage with a doctor, but if intense pain occurs, a person can read the instructions for use and independently decide on the required dose of the drug.

The interval between taking tablets should be at least 4 hours. You can take 1-2 tablets up to 3-4 times a day. You can take no more than 2 tablets at a time; the maximum allowable amount of the drug per day should not exceed 8 tablets.

Without consulting a doctor and his supervision, you can take a remedy to lower your temperature for no more than 3 days. If the medication is used as an analgesic, its use cannot exceed 5 days.

The dose per day can be increased only with the permission of the attending physician. If pain and discomfort persist, you should consult a specialist.

Side effects

If the patient does not exceed the indicated dose, the drug is well tolerated. As side effects from taking the drug, allergic reactions in the form of itching and rashes on the skin are possible. Rare reactions include tachycardia, sleep problems, thrombocytopenia and agranulocytosis.

With long-term use of the drug, the risk of hepatotoxicity increases. If you have any adverse reactions, you should consult a doctor to monitor your body’s condition.

Overdose

The main manifestations of an overdose can be considered vomiting and nausea, pale skin and anorexia. After 1-2 days, signs of liver damage may appear. If the dose is exceeded, you should seek help from a doctor who will prescribe adsorbents and gastric lavage.

Features of application

During pregnancy and lactation

The drug is prohibited for use during pregnancy and breastfeeding.

In childhood

In old age

No dose adjustment is required for this age group.

For impaired renal function

In case of severe disorders, the drug should not be taken.

For liver dysfunction

Patients with significant pathologies of liver function should not take the drug, since paracetamol can provoke liver damage.

The drug Panadol Extra is a combination drug from the group of analgesics and antipyretics.

What is the composition and release form of Panadol Extra?

The pharmaceutical industry produces the medicine Panadol Extra in white tablets, they are so-called capsule-shaped, on one side you can see the embossing in the form of “PANADOL EXTRA”. The combined product Panadol Extra contains two active ingredients, paracetamol and caffeine.

Excipients of the drug Panadol Extra: pregelatinized starch, stearic acid, corn starch, potassium sorbate, talc, povidone, there is croscarmellose sodium, in addition, hypromellose, as well as triacetin. Panadol Extra tablets are sold without a prescription. The shelf life is 4 years.

What does Panadol Extra do?

Analgesic-antipyretic Panadol Extra has an analgesic effect on the body and has an antipyretic effect. The medicine includes two components, one of them is paracetamol, it blocks the so-called cyclooxygenase in the central nervous system, affecting both the pain center and the thermoregulation center. As for the anti-inflammatory effect of the pharmaceutical drug, it is practically non-existent.

The second active component of the pharmaceutical product is caffeine, this is a stimulant substance, it affects the psychomotor centers localized in the brain, stimulating them, in addition, it has an analeptic effect, eliminates increased drowsiness, enhances the effectiveness of analgesics, relieves the feeling of fatigue, and also increases mental performance , as well as physical activity.

What are Panadol Extra's indications for use?

Panadol Extra tablets instructions for use allow use for medicinal purposes in the following cases:

Pain in the lower back;
;
Headache;
;
Migraine;
Neuralgia;
Pain of a muscular and rheumatic nature.

In addition, the pharmaceutical drug Panadol Extra is prescribed for influenza and colds as a symptomatic treatment.

What are the contraindications for use of Panadol Extra?

Panadol Extra (tablets) instructions for use do not allow use for medicinal purposes in the following cases:

;
Epilepsy;
Glaucoma;
, kidneys of a pronounced nature;
;
Hypersensitivity to medication substances;
Up to 12 years;
Do not prescribe tablets simultaneously with other paracetamol-containing pharmaceuticals.

Panadol Extra is prescribed with caution for benign hyperbilirubinemia, viral hepatitis, pregnancy, glucose-6-phosphate dehydrogenase deficiency, breastfeeding, and alcoholism.

What are the uses and dosage of Panadol Extra?

Adults are prescribed Panadol Extra 1-2 tablets 3-4 times throughout the day. The medicine should not be used for more than five days as an anesthetic pharmaceutical, and as an antipyretic, the pharmaceutical can be used for no more than three days without a doctor’s prescription.

The Panadol Extra tablet is swallowed whole, washed down with the required volume of water. The dosage of a pharmaceutical drug can be increased only on the recommendation of the attending physician.

When taking the medicine for a long time, it may enhance the effect of medications from the group of indirect anticoagulants, which may cause an increased risk of bleeding. It is worth noting that caffeine accelerates the absorption of ergotamine.

Overdose from Panadol Extra

It is important to take the drug Panadol Extra in recommended doses; in case of an overdose of tablets, it is necessary to begin gastric lavage as quickly as possible, and enterosorbenes should also be used. If your condition worsens, you should promptly seek medical help, as the patient may experience delayed liver damage of a serious nature, which will require immediate hospitalization of the patient and symptomatic therapy.

What are the side effects of Panadol Extra?

In recommended doses, Panadol Extra is tolerated quite well, only in rare cases, taking tablets can cause a number of side effects: allergic reactions, possible tachycardia, skin rashes, leukopenia, itching, characteristic thrombocytopenia, and possibly methemoglobinemia .

Other adverse reactions to taking the pharmaceutical drug Panadol Extra can be expressed in the form of nausea, agranulocytosis is typical, epigastric pain is observed, hemolytic anemia occurs, and sleep disturbance is possible.

In addition, with long-term use in excessive doses, the development of hepatotoxic and nephrotoxic effects is possible, and pancytopenia is also possible.

special instructions

In cases of long-term use of the pharmaceutical drug Panadol Extra, the patient needs to monitor blood counts. During treatment, you should not drink coffee or tea in excess, otherwise a pronounced state of excitement will arise, the process of falling asleep will be disrupted, arrhythmia will occur, and tachycardia is also possible.

You should not drink alcohol while taking this medication to avoid toxic damage to the liver tissue. The pharmaceutical product Panadol Extra can influence the test results of the so-called doping control of athletes, slightly changing them.

How to replace Panadol Extra, what analogues should I use?

Pharmaceutical drug Darval, medicine Andrews Ansver, drug

Latin name: Panadol Extra
ATX code: N02BE51
Active substance: Paracetamol and caffeine
Manufacturer:
Conditions for dispensing from a pharmacy: Over the counter

Panadol Extra is a drug with a combined composition that has analgesic properties.

Indications for use

The drug is used to relieve moderate to moderate pain that develops against the background of:

• Migraine
• Muscle pain and headaches
• Algodismenorrhea
• Neuralgia
• Pain of rheumatic nature
• Arthralgia.

Panadol Extra can be used to relieve acute symptoms of influenza, ARVI, and colds.

Compound

One painkiller tablet contains two active ingredients, paracetamol and caffeine, their dosage is 500 mg and 65 mg, respectively.
The following additional components are used:

• Stearic acid
• Potassium sorbate
• Purified water
• Talc
• Polividon
• Triacetin
• Croscarmellose sodium
• Pregelatinized starch
• Hydroxypropyl methylcellulose.

Medicinal properties

The therapeutic effect of the drug is due to the special properties of each of the active components.
Caffeine has a stimulating effect on the central nervous system, which is associated with an effect on the psychomotor centers of the brain. This substance relieves drowsiness, a feeling of extreme fatigue and, at the same time, helps to enhance the effect of analgesic components. Caffeine can increase performance (both mental and physical).
Paracetamol exhibits analgesic properties and has an antipyretic effect. The analgesic effect is achieved due to inhibition of the synthesis of special substances (prostaglandins), this effect on the body is due to inhibition of Cyclooxygenase enzymes. In addition, paracetamol influences the process of pain impulse transmission in the nervous system and affects thermoregulation by directly influencing certain areas of the hypothalamus.
After oral administration of tablets, a fairly high degree of absorption of paracetamol in the gastrointestinal tract is observed. After 30-90 minutes. its highest concentration is found in the blood. Metabolic processes occur in liver cells, and metabolites are excreted by the kidneys.

Release form

Price from 42 to 161 rubles.

Panadol Extra is available in the form of regular and effervescent tablets of a whitish color without visible inclusions. The package can contain 10 regular tablets. or 12 effervescent tablets.

Panadol Extra: instructions for use

Panadol Extra (tablets) is intended for oral administration only. The standard treatment regimen for pain syndrome involves taking 1-2 tablets. three or four times a day. In this case, the minimum interval between taking the medicine should not be less than 4 hours. You can drink no more than 2 tablets at a time. The highest daily dosage of Panadol Extra should not exceed 8 tablets.
As an analgesic, taking tablets with Panadol and caffeine is allowed for no more than 5 days; use as an antiperetic drug is allowed for no more than 3 days. If necessary, the doctor can extend the prescribed course of treatment.
If, after a standard course of treatment, there is no improvement in the patient’s condition, you will need to consult a doctor for advice.
If there is no expected positive dynamics in the treatment of pain, a doctor’s consultation is required.

Use during pregnancy and pregnancy

Taking painkillers during pregnancy is possible if there are vital indications.
If there is a need to take Panadol Extra during breastfeeding, you should stop breastfeeding.

Contraindications

Before you start taking regular and effervescent tablets based on paracetamol and caffeine, you should familiarize yourself with a number of contraindications:

• Atherosclerotic changes
• Pregnancy, GW
• Disorders in the hematopoietic system
• Signs of individual sensitivity
• Glaucoma
• Pathologies of the functioning of the renal system and liver
• Insomnia
• Children's age (child under 14 years old)
• Increased blood pressure
• Hyperbilirubinemia
• Lack of glucose-6-phosphate dehydrogenase in the body, caused by disorders at the genetic level.

Precautionary measures

It is not recommended to take increased dosages of medication without consulting your doctor.
It is not advisable to drink tea and caffeine-containing drinks in large quantities; there is a high risk of developing tachycardia, heart rhythm disturbances and insomnia. In the background, this may manifest itself as nervous excitement.
For patients suffering from alcoholism, the drug is prescribed with caution.
Cross-drug interactions
When taking indirect anticoagulants at the same time, their effect on the body increases, and the risk of bleeding increases.
The likelihood of hepatotoxicity increases with the use of inducers of microsomal oxygenation in the liver (barbiturates, Rifampicin, tricyclic antidepressants, Phenylbutazone, as well as Phenytoin and ethanol).
The risk of developing a negative effect on the liver is reduced when taking Cimetidine or other drugs that inhibit microsomal oxidation.
Paracetamol affects the elimination process of Chlorampheniol (increases by 5 times).
Caffeine accelerates the absorption of Ergotamine. When drinking alcoholic beverages, there is a high risk of developing liver pathologies and acute pancreatitis.
When taken in combination with Cholestyramine, a decrease in the rate of absorption of paracetamol is observed. A reverse reaction is diagnosed when taking Domperidone or Metoclopramide.
The medicinal effect of the drug is reduced when using uricosuric drugs.

Side effects

When taking tablets with caffeine and paracetamol, a number of side effects may develop, these include:

• Insomnia
• Methemoglobinemia
• Itchy skin, rashes
• Allergies, including angioedema
• Bleeding disorders
• Leukopenia
• Changes in heart rate (tachycardia)
• Leukopenia
• Agranulocytosis.

With long-term use of the medication, the likelihood of nephrotic as well as hepatotoxic lesions increases. It is necessary to regularly monitor basic blood parameters. If these reactions occur, you will need to stop taking the pills and consult a specialist.

Overdose

When taking excess doses of the drug, the following may occur:

• Tremor
• Excessive nervous excitability
• Severe dizziness
• Impaired sleep quality.

Along with this, adverse reactions from the hematopoietic system and other reactions cannot be excluded:

• Disturbance of metabolic processes, and in particular glucose metabolism
• Violation of the CVS activity
• Development of seizures
• Pale skin
• The occurrence of metabolic acidosis
• Hepatonecrosis.

If such symptoms appear, the gastrointestinal tract should be washed and enterosorbent medications should be taken. For persons with severe signs of overdose, N-acetylcysteine ​​is administered intravenously and Methionine is indicated. Diazepam will help relieve the resulting convulsive syndrome.

Storage conditions and shelf life

Panadol Extra should be stored at a temperature not exceeding 15-25 C; the shelf life of this drug is 4 years.

Analogues

GlaxoSmithKline SK, UK

Price from 71 to 319 rub.

Sopadeine is one of the highly effective painkillers, prescribed to relieve pain of various etiologies. The active ingredients of Solpadeine are paracetamol, caffeine, and codeine. The drug is produced in the form of capsules, regular and soluble tablets.

Pros:

• Quickly relieves moderate and mild pain syndrome
• Several dosage forms
• Has antipyretic properties.

Minuses:

• Not prescribed for children under 12 years of age
• Available with prescription
• Not recommended for epilepsy.

Disease class

• Migraine
• Acute upper respiratory tract infection of multiple and unspecified localization
• Influenza caused by an identified influenza virus
• Pneumonia without specifying the pathogen
• Other and unspecified lesions of the oral mucosa
• Lumbago with sciatica
• Rheumatism, unspecified
• Myalgia
• Neuralgia and neuritis, unspecified
• Fever of unknown origin
• Headache
• Pain not elsewhere classified
• Other constant pain
• Acute tonsillitis, unspecified

Clinical and pharmacological group

• Not indicated. See instructions

Pharmacological action

• Antipyretic
• Analgesic (non-narcotic)

Pharmacological group

• Anilides in combinations

Effervescent tablets Panadol Extra

Instructions for medical use of the drug

• Indications for use
• Release form
• Pharmacodynamics of the drug
• Pharmacokinetics of the drug
• Contraindications for use
• Side effects
• Directions for use and doses
• Overdose
• Storage conditions
• Best before date

Indications for use

Pain syndrome of various origins of mild or moderate severity (headache, migraine, back pain, rheumatic and muscle pain, neuralgia, toothache, menalgia).

To relieve colds, flu and sore throat (relieves pain and reduces body temperature).

Release form

Soluble tablets 65 mg + 500 mg; strip 2 cardboard pack 6;

Soluble tablets 65 mg + 500 mg; strip 4 cardboard pack 6;

Soluble tablets 65 mg + 500 mg; strip 2 pack cardboard 12;

Pharmacodynamics

Paracetamol has an analgesic and antipyretic effect. Caffeine stimulates the central nervous system and enhances the analgesic effect of paracetamol, increasing its concentration in brain tissue.

It is well tolerated and does not irritate the gastrointestinal mucosa.

Pharmacokinetics

Paracetamol and caffeine are well absorbed from the gastrointestinal tract, distributed evenly throughout the tissues, penetrate the brain, and are metabolized in the liver. Both substances and their metabolites are excreted mainly by the kidneys.

Use during pregnancy

The use of the drug during pregnancy is possible only for health reasons.

If it is necessary to use the drug during lactation, the issue of temporarily interrupting breastfeeding should be resolved.

Contraindications for use

Increased individual sensitivity to the components of the drug.

Severe renal and/or liver dysfunction, congenital hyperbilirubinemia, glucose-6-phosphate dehydrogenase deficiency.

The drug is not prescribed to patients suffering from alcoholism, dysfunction of the hematopoietic system (severe anemia, leukopenia), thrombophlebitis, thrombosis, atherosclerosis and arterial hypertension.

The drug is not used to treat patients suffering from insomnia, glaucoma, including angle-closure glaucoma, epilepsy, hyperthyroidism, cardiac conduction disorders, decompensated heart failure, coronary artery disease, prostatic hypertrophy, diabetes mellitus and acute pancreatitis.

The drug should not be prescribed to elderly patients and patients prone to vasospasm.

The drug is contraindicated for use during pregnancy and lactation, as well as for children under 12 years of age.

The drug should be prescribed with caution to patients with liver and/or kidney disease.

Side effects

The drug is usually well tolerated by patients; in some cases, the following side effects have been reported:

From the digestive tract: nausea, vomiting, pain in the epigastric region. In addition, changes in the activity of liver enzymes and toxic liver damage are possible.

From the hematopoietic system: thrombocytopenia, pancytopenia, anemia, including hemolytic, sulfate hemoglobinemia and methemoglobinemia.

From the central nervous system: disturbance of sleep and wakefulness, increased irritability, dizziness.

From the cardiovascular system: arterial hypertension, tachyarrhythmia.

Allergic reactions: skin rash, itching, urticaria, exudative erythema multiforme, Quincke's edema, Lyell's syndrome, anaphylactic shock.

Others: bronchospasm, hypoglycemia, hypoglycemic coma.

Directions for use and doses

2 tables dissolve in 1/2 glass of water and take up to 4 times a day (maximum daily dose - 8 tablets).

Overdose

In case of an overdose of the drug, the development of nephrotoxic and hepatotoxic effects of the drug is possible, as well as the development of disorders of the hematopoietic system (anemia, thrombocytopenia, pancytopenia, leukopenia, neutropenia, agranulocytosis) and the central nervous system (increased excitability, dizziness, disturbance of sleep and wakefulness, tremor) . In addition, the development of tachyarrhythmia, convulsions, pallor of the skin, vomiting, hepatonecrosis, impaired glucose metabolism and metabolic acidosis is possible.

In case of overdose, gastric lavage, intake of enterosorbents and symptomatic therapy are indicated. In case of severe overdose, intravenous administration of N-acetylcysteine ​​and oral administration of methionine are indicated (if the patient is not vomiting). In case of seizures, diazepam is used.

Precautions for use

Should not be used by children under 12 years of age.

Caution must be exercised in severely impaired liver or kidney function.

The risk of overdose increases in patients with non-cirrhotic alcoholic liver diseases.

During treatment, excessive consumption of tea or coffee should be avoided.

Storage conditions

At a temperature not exceeding 25 °C.

Best before date

ATX classification:

N Nervous system

N02 Analgesics

N02B Analgesics and antipyretics

N02BE Anilides

Registration Certificate Holder:
GlaxoSmithKline Consumer Healthcare

Produced:
GlaxoSmithKline Dungarvan Ltd.

ATX code for PANADOL EXTRA

N02BE71 (Paracetamol in combination with psycholeptics)

Analogues of the drug according to ATC codes:

Before using PANADOL EXTRA, you should consult your doctor. These instructions for use are for informational purposes only. For more complete information, please refer to the manufacturer's instructions.

Clinical and pharmacological group

Release form, composition and packaging

White film-coated tablets, capsule-shaped with a flat edge, embossed “PANADOL EXTRA” on one side.

Excipients: pregelatinized starch, corn starch, povidone, potassium sorbate, talc, stearic acid, croscarmellose sodium, hypromellose, triacetin.

12 pcs. - blisters (1) - cardboard boxes.

pharmachologic effect

Analgesic-antipyretic. Has an analgesic and antipyretic effect. Panadol Extra contains a combination of two active ingredients: paracetamol and caffeine.

Paracetamol blocks COX in the central nervous system, affecting the centers of pain and thermoregulation (in inflamed tissues, cellular peroxidases neutralize the effect of paracetamol on COX), which explains the almost complete absence of anti-inflammatory effect. The lack of influence on the synthesis of prostaglandins in peripheral tissues determines the absence of a negative effect on water-salt metabolism (sodium and water retention) and the gastrointestinal mucosa.

Caffeine stimulates the psychomotor centers of the brain, has an analeptic effect, enhances the effect of analgesics, eliminates drowsiness and fatigue, and increases physical and mental performance.

Pharmacokinetics

Data on the pharmacokinetics of Panadol Extra are not provided.

PANADOL EXTRA: DOSAGE

Adults (including the elderly) and children over 12 years of age are prescribed 1-2 tablets. 3-4 times/day, if necessary. The interval between doses is at least 4 hours. The maximum single dose is 2 tablets, the maximum daily dose is 8 tablets.

Increasing the daily dose of the drug or the duration of treatment is possible only under the supervision of a physician.

Overdose

The drug should be taken only in recommended doses. If you exceed the recommended dose, you should seek immediate medical attention, even if you feel well, as there is a risk of delayed serious liver damage.

Symptoms of paracetamol overdose: nausea, vomiting, stomach pain, pale skin, anorexia. After 1-2 days, signs of liver damage are determined. In severe cases, liver failure and coma develop.

Treatment: the victim should undergo gastric lavage, prescribe adsorbents (activated carbon) and consult a doctor.

Drug interactions

When taken for a long time, the drug enhances the effect of indirect anticoagulants (warfarin and other coumarins), which increases the risk of bleeding.

The drug enhances the effect of MAO inhibitors.

Barbiturates, phenytoin, ethanol, rifampicin, phenylbutazone, tricyclic antidepressants and other stimulants of microsomal oxidation increase the production of hydroxylated active metabolites, causing the possibility of severe intoxication with small overdoses.

Microsomal oxidation inhibitors (cimetidine) reduce the risk of hepatotoxicity.

Under the influence of paracetamol, the elimination time of chloramphenicol increases 5 times.

Caffeine accelerates the absorption of ergotamine.

The simultaneous use of paracetamol and alcoholic beverages increases the risk of developing hepatotoxic effects and acute pancreatitis.

Metoclopramide and domperidone increase, and cholestyramine reduces the rate of absorption of paracetamol.

The drug may reduce the effectiveness of uricosuric drugs.

Pregnancy and lactation

The drug should be used with caution during pregnancy and lactation.

PANADOL EXTRA: SIDE EFFECTS

Allergic reactions: sometimes - skin rashes, itching, angioedema.

From the hematopoietic system: rarely - leukopenia, thrombocytopenia, methemoglobinemia, agranulocytosis, hemolytic anemia.

From the digestive system: dyspeptic disorders (including nausea, epigastric pain).

Other: rarely - sleep disturbance, tachycardia.

With long-term use in high doses, the likelihood of hepatotoxicity, nephrotoxicity and pancytopenia increases.

Storage conditions and periods

The drug should be stored out of the reach of children at a temperature not exceeding 25°C. - 4 years.

Indications

• headache;
• migraine;
• toothache;
• lower back pain;
• neuralgia;
• muscle and rheumatic pain;
• painful menstruation;
• symptomatic treatment of colds and flu (to reduce elevated body temperature).

Contraindications

• severe liver dysfunction;
• severe renal dysfunction;
• arterial hypertension;
• glaucoma;
• sleep disorders;
• epilepsy;
• children under 12 years of age;
• hypersensitivity to the components of the drug.

The drug should not be taken simultaneously with other paracetamol-containing drugs.

The drug should be used with caution in cases of benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, glucose-6-phosphate dehydrogenase deficiency, alcoholism, pregnancy and lactation.

special instructions

In cases of long-term use in high doses, monitoring of the blood picture is necessary.

To avoid toxic liver damage, paracetamol should not be combined with alcoholic beverages, or taken by persons prone to chronic alcohol consumption.

Patients suffering from atonic bronchial asthma and hay fever have an increased risk of developing allergic reactions.

May change the results of doping control tests for athletes.

Use for renal impairment

Contraindication: severe renal dysfunction.

Use for liver dysfunction

Contraindication: severe liver dysfunction.